Last modified: 2014-06-09
Abstract
Urinary bladder carcinoma also known as Bladder Cancer (BC) is the seventh most com-
mon cancer worldwide. According to existing statistics, 80% of BC patients had occupa-
tional exposure to chemical carcinogens (rubber, dye, textile, or plant industry) or/and
were smoking regularly during long periods of time. The carcinogens from the bladder
lumen a_ect umbrella cells of the urothelium (epithelial tissue surrounding bladder) and
then subsequently penetrate to the deeper layers of the tissue (intermediate and basal
cells). It is a years-long process until the carcinogenic substance will accumulate in the
tissue in the quantity su_cient to trigger DNA mutations leading to the tumor develop-
ment.
In this talk, I propose a model of BC progression that includes the crucial processes
involved in tumor growth. My collaborator (Kashdan Eugene) and I simulated oxygen
di_usion, carcinogen penetration and angiogenesis within the framework of the urothelial
cell dynamics. The cell living cycle is modeled using discrete technique of Cellular Au-
tomata, while the continuous processes of carcinogen penetration and oxygen di_usion are
described by the nonlinear di_usion-absorption equations. Our model yields a theoretical
insight into all stages of BC development and growth with especial accent on two most
common types of urinary bladder carcinoma: bladder polyps and carcinoma in situ. Our
numerical simulations are in a good qualitative agreement with in vivo results reported
in the corresponding medical literature.