Chalmers Conferences, 9th European Conference on Mathematical and Theoretical Biology

Conditions for oscillations in the NF-kB pathway
Jana Wolf

Last modified: 2014-06-09


The IKK/ NF-kB pathway can be activated by a range of stimuli and lead to the activation of members of the NF-kB transcription factor family. These are critically involved in the control of immune and inflammatory responses, developmental processes, and apoptosis. An aberrant regulation of the pathway is associated with disease states, e.g. chronic inflammation and cancer. The dynamics of the pathway has been studied on the single cell level by a number of investigations. These show a variety of dynamical modes ranging from steady state to transient and sustained oscillatory dynamics. We derive and study a minimal network model to analyze the conditions under which the different dynamics is occurring and to characterize the corresponding system properties.