While the liver is widely accepted as the main site for hepatitis C virus (HCV) production, its role in the
clearance of circulating HCV remains unknown. We investigate this question using standard and
multiscale mathematical models of HCV infection and treatment. The models were fit with frequent viral
kinetic data obtained from blood of patients who underwent liver transplantation (in vivo), and with
detailed intracellular and extracellular HCV RNA kinetic data measured from the HCVcc infection system
(in vitro) during treatment with direct-acting antiviral agents. This is a multidisciplinary team effort that
includes virologists (Natasha Sansone and Susan Uprichard), mathematical modelers (Tje Lin Chung
and Alan Perelson) and clinicians (Scott Cotler, Gonzalo Crespo, Laura Mensa, Sofia Perez-del-Pulgar,
Miquel Navasa, and Xavier Forns).