Chalmers Conferences, 9th European Conference on Mathematical and Theoretical Biology

"Mathematical modelling of the dynamics and the role of the lipid composition in Alzheimer’s disease"
Guido Santos Rosales, Mario Díaz, Néstor Torres

Last modified: 2014-06-09


Alzheimer’s disease (AD) is the most common cause of dementia. There is over 30 million people affected worldwide, and this number is increasing every year. There is not therapy for AD. It is caused by the neural death produce mainly by the toxic effect of amyloid-β, after the APP protein is cut by a specific secretase (BACE). APP and BACE proteins are located in the cellular membrane of the neurons, specifically these proteins are in detergent resistant domains called lipid rafts. It is known that the lipid composition of the lipid rafts plays an important role in the disease, being a very important aspect for finding a cure to AD.Systemic approach to the study of AD let us to quantify the importance of each component of the causal pathway to produce amyloid-β and its relationship with the lipid composition of the membrane. The objective of this work is to use mathematical modeling to understand the role of the membrane composition on AD and try to find an effective therapy for this disease.


Alzheimer; amyliod; lipid rafts