Chalmers Conferences, 9th European Conference on Mathematical and Theoretical Biology

Identifying Optimal Treatment Protocols for the Treatment of a Bacterial Infection in a Chronic Ischemic Wound Using Hyperbaric Oxygen Therapy
Richard Schugart

Last modified: 2014-06-09


While hyperbaric oxygen therapy is a US Food-and Drug Administration ap-

proved therapy for chronic wounds, clinical protocols tend to vary, and optimal

treatment strategies have yet to be identi_ed. In this work, we will identify

optimal treatment protocols for chronic ischemic wounds by using optimal con-

trol therapy on the treatment of a bacterial infection in chronic wounds using

hyperbaric oxygen therapy. While optimal control theory has been successfully

employed to identify treatment protocols for cancer and HIV, optimal control

strategies have yet to be applied for the treatment of chronic wounds. In order

to do so, I will present our optimal-control mathematical models and results for

the treatment of a bacterial infection in a chronic ischemic wound.