Identifying Optimal Treatment Protocols for the Treatment of a Bacterial Infection in a Chronic Ischemic Wound Using Hyperbaric Oxygen Therapy
Last modified: 2014-06-09
Abstract
While hyperbaric oxygen therapy is a US Food-and Drug Administration ap-
proved therapy for chronic wounds, clinical protocols tend to vary, and optimal
treatment strategies have yet to be identi_ed. In this work, we will identify
optimal treatment protocols for chronic ischemic wounds by using optimal con-
trol therapy on the treatment of a bacterial infection in chronic wounds using
hyperbaric oxygen therapy. While optimal control theory has been successfully
employed to identify treatment protocols for cancer and HIV, optimal control
strategies have yet to be applied for the treatment of chronic wounds. In order
to do so, I will present our optimal-control mathematical models and results for
the treatment of a bacterial infection in a chronic ischemic wound.