Chalmers Conferences, 9th European Conference on Mathematical and Theoretical Biology

Image-based computational studies of shear-thinning effects in the progression of cerebral aneurysms
Adelia Sequeira

Last modified: 2014-06-09


Cerebral aneurysms are localized pathological dilations of the brain vessels, due to the weakening of the wall media. They potentially result in the sudden death or morbidity of the patient, through rupture and massive hemorrhage, or by pressing adjacent brain tissue. In the majority of the cases intracranial aneurysms remain asymptomatic until rupture.

In this talk, two different generalized Newtonian mathematical models for blood flow derived for the same experimental data are compared, together with the Newtonian model, in three different anatomically realistic geometries of saccular cerebral aneurysms obtained from rotational CTA. The geometries of the aneurysms differ in size and on the existence or not of side branches.

Results of steady and unsteady simulations can help to understand the impact of the choice of the shear-thinning model to capture the rheological behavior of blood, as well as the possible uncertainty and variability when fitting different shear-thinning models or the Newtonian model to the same experimental data set.

This is a joint work with A. Gambaruto, J. Janela and A. Moura.


cerebral aneurysms; hemodynamics; shear-thinning blood flow model