Cells process information about  their environment and respond appropriately, through complex networks of gene regulation and post-translational modification. Understanding  information processing through these networks and the complexity and sophistication therein is of much importance. In this talk, I will briefly discuss three studies on different aspects of information processing in biochemical networks

(a) At the enzymatic level, we will investigate multisite phosphorylation mechanisms showing how biphasic responses can be obtained in multisite phosphorylation, and how multisite phosphorylation can act as complex signal processors

(b) At the network level, we will present studies investigating how signalling modules may interact with their environment.

(c) Finally, we will present studies elucidating the effects of space in signal transduction both at the enzymatic and module levels