Chalmers Conferences, 9th European Conference on Mathematical and Theoretical Biology

Modelling of platelet-fibrin clot formation in flow with a DPD-PDE method
Alen Tosenberger

Last modified: 2014-06-09


The process of blood coagulation and clot formation in vivo is not yet completely understood. One of the main questions related to haemostasis is why the clot stops growing in normal conditions before it completely obstructs the flow in the vessel, whereas, in pathologic cases, it can continue to grow, often with fatal consequences. Hence, revealing the mechanisms by which the clot grows and stops growing in the flow remains of great importance.  In order to study this topic we have developed a hybrid DPD-PDE method where Dissipative Particle Dynamics (DPD) is used to model plasma flow and platelets, while the protein regulatory network is described by a system of partial differential equations. The model describes interactions between the platelet aggregation and the coagulation cascade. As a result of modelling we propose a new mechanism of clot growth and growth arrest in flow.


Blood coagulation; hybrid model; Dissipative Particle Dynamics