Complex concentration coupling in chemical reaction networks

Last modified: 2014-06-09

#### Abstract

Invariant flux ratios, obtained within flux coupling analysis, as well as invariant complex ratios, derived within chemical reaction network theory, can characterize robust properties of a system at steady state like absolute concentration robustness (ACR). Basically, the detection

of ACR can be reduced to the problem of coarsening partitions of the set of complexes, called complex concentration coupling, independently of the deficiency of the given reaction network. Herein we describe properties of reaction networks that make the coarsening of the corresponding partition tractable. Furthermore, we describe a simple algorithm for the generation of chemical reaction networks with needed properties.